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Proteomics & Integrative Bioinformatics Lab

Advancing Proteomics, one spectrum at a time

  • About the laboratory

    Our research interests are in the fields of proteomics and integrative bioinformatics. On the bioinformatics side, we are focusing on the development of computational methods and tools for processing and extracting biological information from complex biological datasets. This includes computational and statistical methods for mass spectrometry-based proteomics, interactome analysis using affinity purification mass spectrometry (AP-MS) technology, proteogenomics, metabolomics, global analysis of RNA-Seq transcriptome and proteome profiles, and multi-omics data integration (RNA-Seq, proteomics, genomics, etc.) for reconstruction of pathways deregulated in cancer. Our lab has developed and maintains many computational resources widely used by the proteomics community worldwide.

    In 2015 our lab has expanded to include the Proteomics Resource Facility (PRF) at the University of Michigan. Directed by Dr. Nesvizhskii, PRF aims to provide state-of-the-art instrumentation, technical expertise and bioinformatics support to the University of Michigan research community. We are actively collaborating with many biologists and translational scientists, at the University of Michigan and internationally, on a wide range of projects that involve proteomics technology. Taking advantage of our strengths in bioinformatics, we are also developing new and improved proteomics methods such as Data Independent Acquisition (DIA) mass spectrometry for improved label-free protein quantification.

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  • Several appealing ways to present information

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  • Numerous appealing ways to present information

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